The lesson on “Resistant Materials” explains the proper use of screws to join wood, metal, and plastic, emphasizing the selection of the right type and size, such as flathead, Phillips, square, and torque heads, for efficient and secure projects. The instructor advises on the importance of drilling pilot holes to prevent splitting wood and offers techniques for both DIY enthusiasts and those considering professional help. The video also covers nuts and bolts, highlighting their semi-permanent nature, and concludes with a resource for further education on tools like impact drivers.