In the second lesson on food safety, the importance of safety considerations while cooking is emphasized. Key points include maintaining cleanliness by washing hands and sanitizing surfaces, using different colored chopping boards for various food types, and ensuring proper cooking temperatures to avoid food poisoning. Students are reminded of four essential food safety keywords: Cook, Clean, Chill, and Separate, which are crucial in food preparation. The lesson concludes with a focus on proper storage techniques to prevent bacterial growth in leftover food.